This result is in consistent with the previous findings on the antitumor effects of miRc [ 24 ]. C and D.
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It has been shown that miRNAs are frequently associated with chromosomal instability and amplification in multiple human cancers [ 17 ]. As a key factor of tumor metastasis, GIT1 protein level was significantly increased while its mRNA level was only elevated slightly in metastasis mouse model, which suggested that the expression of GIT1 is posttranscriptionally regulated in the process of breast cancer metastasis. Negative controls were incubated with serum instead of primary antibody under the same conditions. The multifunctional GIT family of proteins.
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Quantitative analysis of cell migration in MCF-7 cells of each group. Cell Prolif.
Therefore, miRNAs potentially function as new promising targets for cancer diagnosis and therapeutics [ 19 ]. Biochem Biophys Res Commun. Competing interests The authors declare that no competing interests exist.